This genetic defect blocks various enzymes and other vital pathways to properly metabolize essential nutrients. Toxins affect methylation, sulfation, BH4, Folate & NOS. Heavy metals block enzymes and enzyme cofactors in metabolic pathways such as the urea cycle, BH4 cycle, folate cycle, methylation cycle and sulfation pathway. Detoxification improves the function of most pathways. Detoxification of certain heavy metals must be implemented with caution and systematically, as it could worsen a CBS SNiP and Methionine Synthase SNiP. Specific nutrients can avoid this from occurring with vitamin and mineral cofactors or precursors to make SNiP enzymes function and improve DNA, RNA, glutathione and detoxification.
Sulfation defects can be corrected with a specific method of detoxification and appropriate nutrients.